The candidate will study the fundamental mechanisms by which tumor cells modulate their environment to prevent their destruction by immune cells, specifically CD8+ T lymphocytes. To this end we will develop state-of-the art EM tools to obtain a 3D view of tumors and their microenvironment. The new EM technology will be applied to monitor the effect of known and new immunotherapeutics in established mouse models of breast cancer. The project is in collaboration with Dr. Jacob Hoogenboom at TU Delft and Dr. Shannon Turley at Genentech, San Francisco.
The lab focuses on the role of the endo-lysosomal system in disease and is specialized in the development and application of advanced electron microscopy (EM) methods. We are embedded in a dynamic research environment with international and interactive research groups and direct access to a large number of facilities. Local training opportunities include molecular cell biology, biochemistry, live-cell imaging techniques and correlative light – EM. See also:
A master degree in life sciences, biomedical sciences or a related field. Experience and/or sincere interest in cancer biology and technical microscopy development are required. The PhD position will be for a fixed term of four years and is expected to result in a PhD thesis. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch University Medical Centers.
The maximum salary for this position (100%) is € 2.919,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 4 years.
As a PhD candidate you will be enrolled in the Graduate School of Life Sciences, which is co-organized by three faculties: University Medical Center Utrecht, the Faculty of Veterinary Medicine, and the Faculty of Science. This combination is unique and has gained a strong international reputation in biomedical and life sciences research. The Graduate School of Life Sciences provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit https://www.uu.nl/en/education/graduate-school-of-life-sciences for more information.
To apply, please send one PDF document 1) a letter of motivation, 2) a detailed CV, 3) a BSc and MSc grade list 4) name and contact details of 2 references to email@example.com. The position should be filled by December 31, 2017.
If you have any questions about this vacancy, please contact Mrs.Prof.dr. J. Klumperman, Afdelingshoofd Celbiologie, phone 088 75 56550. Email firstname.lastname@example.org.
Acquisition based on this jobopening is not appreciated.