As postdoc you will be working on data from Project MinE (www.projectmine.com). This is unique genomic dataset in the field of Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles, which include epigenetic, whole genome sequencing and clinical data of several thousand of ALS patients and matched controls. We have recently published the first results of this dataset (Van Rheenen et al. Nat Genet. 2016 (PMID: 27455348), and Kenna et al. Nat. Genet. 2016 (PMID: 27455347)).
Your focus will be on exploring adding external controls and cases to this dataset while preserving type I error in case-control comparisons, annotating the non-coding genome by integrating our data with other publicly available omics datalayers, including RNAseq, Hi-C and Chip-seq and relating this to case-control status. Another type of genomic variation potentially related to ALS we are interested in, is structural variation. This means you need to have experience in working with raw sequencing data on a large number of samples and be able to apply complex genetic statistics in this context. There is a suitable ICT setup available for you to achieve this.
We expect you to be able to use various bioinformatic tools on next-generation sequencing data and combine these to identify possible novel ALS risk genes, and pathological pathways. Also, we would like you to integrate these genetic data with drug databases in order to prioritize potential new drug targets for ALS and repurposing of existing drugs for ALS. This part of the work will be done in collaboration with a biotech company.
You will also be expected to participate in writing scientific papers and grant applications, provide methodological advice to other members of the team (bioinformaticians, PhD students, postdocs, technicians), and participate in educating bachelor and master students.
You will be working at the Brain Center Rudolf Magnus (BCRM) at the UMC Utrecht. The BCRM encompasses research and patient care in neurology, neurosurgery, psychiatry, rehabilitation and sports medicine as well as basic neurosciences and pharmacology. Priority areas are developmental disorders; psychotic disorders; motor neuron diseases; stroke; and refractory (child) epilepsy. These subjects link a common interest in structure & connections, genetic and environmental risk-factors, translational approaches and the relevance of research observations for patient care.
You have a PhD in biostatistics or complex genetics or in combination with next-generation sequencing and affinity with neurodegenerative diseases. You should have extensive experience - shown from scientific publications - in statistical testing and bioinformatics scripting using next-generation data. In order to handle large genomic datasets, including genotyping data but also raw genomics data, you should also have experience in the use of biochemical databases.
You are curious, enthusiastic and results-driven. You have excellent communication skills, a clear style of writing in the English language, and experience in writing research proposals.
The maximum salary for this position (100%) is € 4.152,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 2 years.
If you have any questions about this vacancy, please contact Mr.Prof. dr. J.H. Veldink, Hoogleraar Neurogenetica, phone 088-75 57939. Email J.H.Veldink@umcutrecht.nl.
Acquisition based on this jobopening is not appreciated.