Werken bij UMC Utrecht
Vacancy number: 2018/0907
Apply to: January 01 2019
(gewijzigde einddatum)
Education: University
Employment: Temporary position
Full-time/Part-time percentage: 100%

The postdoctoral fellow will perform his/her research activities in a very close collaboration between the department of Rheumatology & Clinical Immunology of the University Medical Center Utrecht (UMCU) and the Immunology Division of the Faculty of Veterinary Medicine (FVM) of the Utrecht University. These departments are partners in developing tolerogenic dendritic cell (tolDC) therapy for rheumatoid arthritis. We are looking for an enthusiastic postdoc candidate that will be involved in a collaborative project with the UMCU and the FVM. The project focuses on the therapeutic potential of tolDC as novel cellular therapy in rheumatoid arthritis. The main goal is to answer the critical question: are tolDC safe and are they capable of inducing antigen specific regulatory T cells in humans to such extent that therapeutic tolerance can be expected in rheumatoid arthritis? Therefore, development of immunomonitoring assays for the detection of antigen specific T cells is essential. Such assays can be used as response predictors, and therefore be important in the process of patient selection for this treatment and measuring responses to tolDC treatment in patients after treatment. Furthermore, the postdoc will be involved in the set-up of a clinical trial with tolDC therapy in rheumatoid arthritis.


Since everyone deserves the best possible healthcare, UMC Utrecht always sets the bar high. The result: innovative, cutting-edge medical treatment that meets the healthcare needs of today and the future. We develop our unique knowledge in this respect together with patients, patient organizations and several partners. Our doctors, researchers and students join forces to solve major medical issues. Patients at UMC Utrecht receive treatment specifically geared to their specific individual needs. Everything we do is aimed at making and keeping people healthy – and at preventing sickness too. Our physicians, researchers, and graduate students work together to find solutions for a wide range of major medical issues. At UMC Utrecht, we want to prevent and cure disease through patient centered care that is tailored to the needs of the individual. We work every day so that our research, methodologies, and treatments can serve society because we believe everyone deserves the very best care. UU: Utrecht University has great ambitions for its teaching quality and study success rates. This also applies to its clear research profiles which are centered around four themes: Dynamics of Youth, Institutions for Open Societies, Life Sciences and Sustainability. Utrecht University plays a prominent role in our society and contributes to finding the answers to topical and future societal issues. The Faculty of Veterinary Medicine of Utrecht University (FVM-UU) is the only Veterinary School in the Netherlands and belongs to the international top in education, research and veterinary medical patient care. FVM-UU is one of the few European veterinary schools accredited by the American and Canadian Veterinary Medical Associations and the European Association of Establishments for Veterinary Education. The faculty employs approximately 1,000 veterinarians, scientists and support staff and counts 1,500 students.


The postdoc should have experience with research in the field of immunology, advanced experience with flow cytometry, experience in purification and handling immune cells, and preferably experience with dendritic cell cultures. He or she is used to carrying out internationally competitive research, as demonstrated by scientific publications , experience in successfully designing and developing new experiments, experience with analyzing and interpreting experimental data. You should have the ability for creative and original research of the highest impact, ability to multi-task and organize your own work with minimal supervision, ability to maintain a clear and up-to-date lab notebook and deliver written reports, and ability to communicate results effectively at meetings and conferences. You should have excellent verbal and written communication skills, which will be helpful in a.o. setting up and organizing clinical trial activities. Animal experimentation is part of this project. The postdoc will work in close collaboration with PhD students working on underpinning basic research projects, targeted towards the delivery of peptides to in vivo residing tolDCs with the use of innovative nanoparticle delivery systems and the fundamental aspects of tolerance induction and maintenance during health and inflammation. The research activities will be embedded in an existing network of Dutch immunologists and carried out in collaboration with groups in Newcastle (UK), Barcelona (Spain) and Brisbane (Australia).

The maximum salary for this position (100%) is € 4.321,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 2 years.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses, career opportunities and personal budget. The terms of employment are in accordance with the Cao University Medical Centers (UMC).


Additional information: If you have any questions about this vacancy, please contact prof.dr. F. Broere (via phone +31 30 253 18 72 or email f.broere@uu.nl) or dr. M.C. van der Goes (via phone +31 88 75 742 86 or email m.c.vandergoes@umcutrecht.nl) or prof. dr. W. van Eden (via phone +31 30 253 43 58 or email w.vaneden@uu.nl).

More information

If you have any questions about this vacancy, please contact Mrs.M.C. van der Goes, MD PhD, rheumatologist via phone +31 (0)88 75 742 86 or email m.c.vandergoes@umcutrecht.nl.

Acquisition based on this jobopening is not appreciated.

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