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Vacancy number
2010/0502
Department
Nefrologie en Hypertensie
Your profile
Candidates must be highly motivated with doctoral training in biology, developmental biology, medical biology, molecular biology, medicine or other closely related life sciences. Experience in animal experiments is desired (article 9). Candidates should should be willing to work in a interdisciplinary environment with both biologists and clinicians. Applicants should have excellent written and oral communication skills.
Your position
he department of Nephrology and Hypertension is part of the Utrecht Cluster of Cardiovascular Translational Biology and participates in the Institutional Regenerative Medicine Programme. One important research line focuses on renal and vascular regeneration. It involves fundamental research and animal experiments on the role of adult stem- and progenitor cells in vascular and renal regeneration as well as evaluation of stem and progenitor cell dysfunction in patients with cardiovascular and renal disease. In addition the department of Nephrology is involved in clinical studies evaluating the effects of stem cell therapy in patients with vascular disease. The project: ‘Towards a clinical strategy of bone marrow-derived progenitor cell therapy to halt progression of chronic kidney disease’ is supported by a VIDI grant from the Netherlands Foundation of Scientific Research (NWO).
Chronic kidney disease, due to its progressive nature and associated cardiovascular morbidity and mortality, is a major health problem worldwide. New interventions to slow or prevent disease progression are needed. We demonstrated that bone marrow-derived stem and progenitor cells contribute to renal regeneration. Overall aim of the current project is to investigate whether stem cell-based therapy can prevent progression of chronic kidney disease. We will investigate whether administration of stem cells from adult donors prevents progression of chronic kidney disease in a rat model and study the potential effects of stem cell dysfunction. Techniques that will be used include animal experiments (chronic non-invasive follow-up as well as acute instrumentation for administration of stem cells or terminal measurement of renal function, kidney transplantations), cell culture, flow cytometry, and immunohistochemistry.
A full-time position for a period of 4 years. The aim is to obtain a PhD degree.
The maximum monthly salary for this 100% position is €2673.00 gross on the basis of full-time employment (working week of 36 hours).
This is a temporary appointment for 4 years.
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Questions
Want to know more about the job content? Call Mrs prof.dr. M.C. Verhaar, hoogleraar Experimentele Nefrologie, Phone 088 7557329, Beeper 3375 via +31 88-755 5555.
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