Mutations in genes encoding the key components of the cardiac muscle cause diseases referred to as cardiomyopathies. Since the genetic defect is inheritable, cardiomyopathies affect several members of a family and may strike at a young age. Thereby, inherited cardiomyopathies pose an enormous economic and societal burden. The identification of the underlying gene defect early on may allow for the timely application of preventive and curative therapies. However, inherited cardiomyopathies are characterized by extreme clinical heterogeneity in their presentation. The mutation alone is not sufficient to predict clinical course.
The Double Dose-consortium aims to unravel the mechanism by which cardiomyopathy-causing mutations lead to ultrastructural changes in cardiomyocytes. The Double Dose program is financed by the Netherlands Heart Foundation and Stichting Hartedroom. Our consortium combines experts in preclinical research, clinical genetics, health technology assessment and clinical researchers with a strong clinical focus on cardiomyopathy in children and adults. More information can be found here: https://dcvalliance.nl/our-consortia/double-dose
The expected date for the vacancy to start is September 2021. The aim of the project is to investigate the (metabolic) consequences of a genetic mutation on a subcellular level. You will integrate the analysis of whole transcriptome and proteomics data from cardiac tissue and induced pluripotent stem cell derived cardiomyocytes to study disease progression in genetic cardiomyopathies. You will employ high-resolution imaging and high-throughput automated image analysis to study structural differences in morphology and protein expression.
Cardiovascular researchers, clinicians and educators from UMC Utrecht have assembled into one program: Circulatory Health. The mission of our program is to reduce the burden of cardiovascular disease worldwide.
You are an ambitious MSc with a strong interest in cardiology. You should hold a degree or have expertise in bioinformatics. You are a strong team player as we believe that a supportive work environment is behind the scientific success.
The maximum salary for this position (36 - 36 hours) is € 3.196,00 gross per month based on full-time employment. This job is based on a permanent position, starting with a contract for a year.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
If you have any questions about this vacancy, please contact dr. M. (Magdalena) Harakalová, Assistant professor, phone number: 088 75 570 65, e‑mail adress: M.Harakalovafirstname.lastname@example.org.
Acquisition based on this jobopening is not appreciated.