Our research focusses on immune regulatory mechanisms in chronic pain and inflammation. We have elucidated that cytokines, molecules well known for their role in the immune system, effectively regulate neuronal feedback circuits that shut down pain. Based on these insights we have developed a novel technology to fuse endogenous anti-inflammatory cytokines to treat chronic pain. To further the concept of using fusion proteins, we are currently expanding our efforts to develop and modify new fusion proteins of regulatory cytokines to treat chronic pain and/or inflammatory disease. You will be the principal responsible for execution and management of this NWO-funded project. You will design, produce and purify new fusion proteins and aim to understand their working mechanisms in vitro. Moreover, you will manipulate these fusion proteins to selectively target specific receptor chains to improve biological functions. For this, you will work independently and collaborate with multiple scientists in our team. Experience with molecular biology and techniques, protein expression, RNAseq, kinase profiles, in vitro cell cultures is a pre-requisite. Experience in neuro-immunology and willingness to perform animal experiments is an advantage.
The laboratory for neuro-immunology of pain is hosted in the in the Center of Translational Immunology (CTI) at the UMC Utrecht. The group of Eijkelkamp is composed of an international team of researchers that are actively collaborating on projects to better understand chronic pain and develop novel therapeutic strategies to kill pain and inflammation. We are interested in the mechanisms of chronic pain, and specifically in the biology of cytokines in pain regulation and how we can use these cytokines in treating chronic pain. Therefore, we perform basic and translational studies in vitro and in vivo with the aim to translate our findings into the clinics. The CTI is a well-facilitated department with experts in all fields of immunology, and is embedded in the focus area ‘Infection and Immunology’ of the UMC Utrecht. We are structured to facilitate bench-to-bed side research. We have a state-of-the-art flow cytometry, imaging and antibody development facility (UMAB) and ample experience in protein production though our protein facility.
We are looking for talented and highly motivated postdoctoral candidates with a PhD degree in biomedical sciences, preferably in molecular biology. You have excellent experimental skills and preferably experience in molecular biology, protein development and purification, (primary human) cell culture, and flow cytometry. You should have good communication skills and organizational talent. The candidate should be able to acquire additional research funds, be flexible, versatile and a good team player. Affinity with neuro-immunology is preferred as well as the willingness and certification to perform animal experiments.
The maximum salary for this position (80%) is € 4.481,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for Appointment for 1 year, possible extent up to three year.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
You will be employed on the basis of 80-100%. Appointment is for one year, with a possible extension of up to three years. The project starts in November 2019. Your application should include a motivation letter, a CV, a brief description of past research experience
If you have any questions about this vacancy, please contact Niels Eijkelkamp, PhD; phone number: 0887554354; e mail address: email@example.com
If you have any questions about this vacancy, please contact Mr.Niels Eijkelkamp, Associate Professor, phone number: 088 755 4354, e‑mail adress: firstname.lastname@example.org.
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