The successful applicant for this research technician position in tumor immunology will be part of the team that directly contributes to a phase I clinical study testing the safety and feasibility of engineerd T cell therapy such as TEGs and CAR T cell products. The work involves using viral vector-based techniques to engineer primary T cells in both research and GMP environments, and evaluating patient samples using flow cytometry or qPCR techniques. The isolation and culture of primary human immune and tumor cells are also part of the work, as well as setting up, developing and validating new methods and techniques to produce engineered T cells.
The technician will be part of the ATMP development group supervised by Trudy Straetemans within the larger research group of Jurgen Kuball and Zsolt Sebestyen and is embedded in the Tumor Immunology section of the Center for Translational Immunology. It focuses on the development of immune interventions against cancer using immune cells and their receptors. A unique research pipeline from fundamental to translational and clinical research has been established. A key concept developed in this group is a new generation of engineered immune cells named TEGs (T cells Engineered to express a defined Gamma delta T cell receptor). These are currently being tested in a phase I safety/feasibility clinical study at the University Medical Center Utrecht.
You have a Bachelor of (Applied) Science (BSc) degree or Master of Science (MSc) (or equivalent) in a relevant biomedical field. You are experienced in cellular (cell culture, cell engineering, flow cytometry) and molecular biological techniques.
You have a professional level of proficiency in Dutch and English (written and spoken) and are able to think analytically, and have problem-solving skills and a drive to succeed. While you’re able to work independently, you’re also an effective member of a team and have the social skills essential for ensuring fruitful interactions. Not only are you enthusiastic, flexible and accurate in your work, you’re also keen to join an interdisciplinary and international environment. Training and experienced in working under the GMP quality system is an advantage.
We believe in the power of a diverse team in which there is room for different skills, expertise, and social and cultural backgrounds. We invite you to respond to this vacancy.
The maximum salary for this position (36 - 36 hours) is € 3.280,00 gross per month based on full-time employment.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
If you have any questions about this vacancy, please contact Trudy Straetemans, Asssistent professor, phone number: 0887554306, e‑mail adress: G.C.M.Straetemans@umcutrecht.nl.
Acquisition based on this jobopening is not appreciated.