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Vacancy number: 2020/0127
Apply to: March 1 2020
Education: Bachelor
Employment: Temporary position
Full-time/Part-time percentage: 100%

We are looking for a highly motivated computational biologist skilled in bioinformatics/data mining (Bachelors/HBO level). You will research (whole genome) sequencing cancer data in the context of various ongoing studies and help design validation and novel follow-up research projects. You will perform data analyses on large pan cancer WGS datasets and on single samples obtained from in vitro manipulation studies. Therefore, a good understanding of molecular (cancer) biology and experience in WGS datasets is not required but considered as a strong plus. Together with wetlab team members, you will also explore novel WGS techniques and be responsible for the computational analyses. The candidate should have a demonstrable computational and language scripting experience and should be able to work independently and with colleagues on joint projects. The candidate will be working on a temporary project (no PhD trajectory available); as such the appointment will be for 1 or 2 years with a possibility for extension.

Department

The Center for Molecular Medicine (cmm.umcutrecht.nl) uses experimental, genomics and bioinformatics approaches to understand the genetic basis of disease with a specific focus on cancer and congenital disease. Expertise and state-of-the-art infrastructure is available for next-generation DNA sequencing, single molecule sequencing, proteomics, metabolomics, bioinformatic data analysis and data mining, imaging and microscopy and a broad range of model systems, including patient-derived primary cultures, iPS cells and organoid culturing. The Cuppen group is a translational research group, embedded in the Center for Molecular Medicine and the national Oncode Institute, that investigates the causes and consequences of genetic and genomic variation with a main focus on cancer. For this, we study complete genomes of patient derived samples and experimental in vitro models using the latest DNA sequencing technologies. Interpretation of alterations at the single base letter and structural level in both protein-coding and regulatory domains is one of the main challenges that we address using systematic integrative experimental and computational approaches. Furthermore, we are studying the origin and mechanisms by which genetic mutations are induced and how genetic variation impacts on tumorigenesis and treatment response. Our research is performed in a highly collaborative fashion both within the group and with other research groups and clinical laboratories and researchers on a local, national and international level. These collaborations are important for translating fundamental knowledge into clinical practice and routine diagnostics.

Profile

You have advanced skills as a bioinformatician or data scientist You have a high level of proficiency in R and/or python You have understanding of molecular (cancer) biology You have a high intrinsic motivation and a strong scientific curiosity

The maximum salary for this position (100%) is € 3.184,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 24 months.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

More information

If you have any questions about this vacancy, please contact Mr.prof.dr. Edwin Cuppen, PI, phone number: 06 50 12 49 92, e‑mail adress: ecuppen@umcutrecht.nl.

Acquisition based on this jobopening is not appreciated.

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