Gene regulation a major driving force in development and differentiation. Therefore, faulty gene regulation lies at the heart of the majority of diseases. The 3D-architecture of the genome has been shown to have a profound effect on gene regulation. So far, the investigation of this architecture has been limited to the identification of DNA-DNA contacts.
However, the recent discovery that the transcriptional machinery forms biomolecular condensates (“protein droplets”) tells us that protein-protein and protein-DNA contacts are equally important. The candidate will study how the interplay of DNA architecture and biomolecular condensates affects the transcriptional activation of oncogenic signaling pathways using state-of-the-art live cell imaging, genome engineering and chromosome conformation capture approaches.
The Center for Molecular Medicine focuses on understanding the molecular basis of disease. The Center is part of the Division Laboratories, Pharmacy and Biomedical Genetics of the UMC Utrecht and comprises the Sections Molecular Cancer Research, Cell Biology, Stem Cells and Genetics. Within the institute, multidisciplinary fundamental and translational research is performed in relation to various diseases, including cancer, chronic inflammatory and genetic disorders. The aim of the CMM is to train the next generation of biomedical scientists and medical doctors by performing internationally leading, fundamental biomedical research and by offering stimulating and excellent education.
You have a Master’s degree in biomedical sciences or a related field. The candidate should have a genuine interest in basic biology and has experience with bioinformatics and molecular cell biology. Experience and in-depth knowledge of cell- and molecular- biology are required. Moreover, experience with fluorescent microscope imaging image analysis is an advantage. We are looking for a motivated team player with excellent English communication skills, who will take responsibility for their own research project and is passionate about fundamental biological questions.Salary and benefits are in accordance with the Collective Labour Agreement for Dutch University Medical Centers.
The maximum salary for this position (100%) is € 3.103,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 4 years.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
If you have any questions about this vacancy, please contact Mr.Jurian Schuijers, Assistant Professor, phone number: 088 75 507 01, e‑mail adress: J.Schuijers@umcutrecht.nl.
Acquisition based on this jobopening is not appreciated.