We have developed a technology to fuse endogenous anti-inflammatory cytokines to improve their therapeutic potential to inhibit inflammatory responses. Currently we are expanding our efforts to develop and modify these fusion proteins of regulatory cytokines to treat chronic pain and/or inflammatory disease. For this TKI-funded project, you will be responsible for execution and management of the project. You will investigate whether the new technology can be used for systemic treatment of inflammatory diseases by evaluating the therapeutic potential and mechanism of fusion protein variants in vivo in murine models and in a human in vitro model for sepsis and inflammatory bowel disease. For this, you will work independently and collaborate with multiple scientists in our team. Experience with molecular techniques (cloning), protein expression/ purification, and in vivo models is a pre-requisite. Experience with specific colitis and sepsis models is an advantage.
The laboratory for neuro-immunology of pain is hosted in the in the Center of Translational Immunology (CTI) at the UMC Utrecht. The group of Eijkelkamp is composed of an international team of researchers that are actively collaborating on projects to better understand chronic pain and develop novel therapeutic strategies to kill pain and inflammation. We are interested in the biology of cytokines in the regulation of pain and inflammation and how we can use fusion protein of these cytokines in treating these conditions. Therefore, we perform basic and translational studies in vitro and in vivo with the aim to translate our findings into the clinics. The CTI is a well-facilitated department with experts in all fields of immunology, and is embedded in the focus area ‘Infection and Immunology’ of the UMC Utrecht. We are structured to facilitate bench-to-bed side research. We have a state-of-the-art flow cytometry, imaging and antibody development facility (UMAB) and ample experience in protein production though our protein facility.
We are looking for talented and highly motivated postdoctoral candidates with a PhD degree in biomedical sciences, preferably in immunology. The candidate should have excellent experimental skills and preferably have experience in molecular biology, protein purification, (primary human) cell culture, flow cytometry and in vivo animal models. The candidate should have a permit (art. 9) to perform animal experiments, have good communication skills and organizational talent. The candidate should be able to acquire additional research funds, be flexible, versatile and a good team player.
The maximum salary for this position (100%) is € 4.481,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 2 years.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
You will be employed on the basis of 36 hours per week. Appointment is for two years. The project starts in November 2019. Your application should include a motivation letter, a CV, a brief description of past research experience.
If you have any questions about this vacancy, please contact Niels Eijkelkamp, PhD; phone number: 0887554354; e mail address: firstname.lastname@example.org
If you have any questions about this vacancy, please contact Mr.Dr. Niels Eijkelkamp, Associate Professor, phone number: 088 755 4354, e‑mail adress: email@example.com.
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